Synthetic Mesh Holds Its Ground: Comparable Efficacy and Safety in Preventing Incisional Hernias Post Ileostomy Closure

In the Preloop trial, 97 patients underwent loop ileostomy closure with either retrorectus synthetic or biological mesh. Results at 10 months showed comparable outcomes—2% incisional hernia rates in both groups, and no significant differences in complications, reoperation rates, or hospital stay. The findings suggest synthetic mesh’s efficacy and safety match up to its biological counterpart, challenging the notion of avoiding synthetics in contaminated surgical sites. A mesh choice dilemma resolved for surgeons in the quest to prevent incisional hernias.