Tailored Antibiotic Prophylaxis Cuts Surgical Site Infections

An antimicrobial stewardship program tailored for pancreatic surgery significantly reduced surgical site infections (SSIs) linked to colonized bile. In a study of 1,638 pancreatoduodenectomies, the program cut overall SSI rates by 34% and superficial SSI rates by 59%. Importantly, the predictive value of intraoperative bile culture for SSIs diminished post-implementation, underscoring the efficacy of personalized surgical antibiotic prophylaxis in managing colonization.