Postcolonoscopy Colorectal Cancers Reveal Distinct Molecular Patterns

Postcolonoscopy colorectal cancers (pccrcs) show higher rates of microsatellite instability, CIMP, and BRAF mutations compared to sporadic cases, alongside a greater presence of proximal lesions. Although 5-year survival rates are similar between pccrcs and sporadic colorectal cancers, pccrcs fare significantly worse than cancers detected via screening. These findings suggest the serrated pathway’s pivotal role in pccrc development, highlighting the urgency for enhanced detection strategies for clinically significant serrated lesions.