Plasma Proteomic Profiles Enhance Diverticulitis Risk Prediction Accuracy

A novel plasma proteomic risk score significantly refines the stratification of severe diverticulitis risk. This comprehensive study, analyzing data from over 43,000 patients, reveals a strong association between specific protein profiles and heightened risk of severe disease. The inclusion of proteomic data alongside genetic and lifestyle factors notably improved prediction models, increasing their accuracy for clinical application. Insights into related renal and cardiometabolic conditions further underscore the potential of proteomic signatures in clinical risk management.