Hepatectomy with Bile Duct Resection Hinders Adjuvant Chemotherapy in Biliary Tract Cancer Patients

In a retrospective analysis of 168 biliary tract carcinoma patients post-surgery, 83.9% received adjuvant chemotherapy, while 16.1% did not. Notably, hepatectomy with extrahepatic bile duct resection (BDR) significantly hindered chemotherapy administration compared to other surgeries. Refractory bile leak, primarily post hepatectomy with BDR, was a common reason for non-administration. Multivariate analysis identified hepatectomy with BDR and preoperative anemia as independent factors associated with the difficulty of adjuvant chemotherapy, emphasizing the need for alternative strategies in such cases.