Laparoscopic enucleation is a safe, efficient option for large benign or low-grade malignant pancreatic tumors.

• No difference in perioperative complications between large and small tumor patients undergoing laparoscopic enucleation.
• Laparoscopic enucleation significantly reduces operative time (160 vs. 397 minutes) compared to standard pancreatectomy procedures.

Surgeons may consider laparoscopic enucleation to optimize surgical outcomes without increasing risks in larger tumor cases.