Low physical activity is significantly increasing colorectal cancer rates in China and the US, underscoring the need for targeted intervention.

• In 2021, China saw 16,698 CRC deaths from low physical activity, a 191% increase since 1990.
• The US reported an 18% rise in CRC deaths from low activity, suggesting a growing need for preventative measures tailored to younger populations.

Increased awareness and public health initiatives are crucial to combat this trend and improve outcomes.

• The projected burden of CRC is expected to rise further by 2036, highlighting an urgent need for action.