Current literature shows significant variability in the definitions of colon cancer segments, affecting treatment and outcomes.

• Only 10% of studies provide clear definitions for colon segments, risking inconsistent outcomes.
• The majority of defined segments are for the splenic flexure (58.5%) and transverse colon (42.9%), while others like the cecum and ascending colon are severely lacking.

Surgeons should prioritize using standardized segment definitions for improved accuracy in patient management and research outcomes.