Intraoperative blood loss is a key risk factor for postoperative pancreatic fistula (POPF) in pancreatic surgery, impacting patient recovery.

• Among 13,108 patients, the overall POPF rate was 20%.
• In patients with POPF, intraoperative blood loss was 112.46 ml higher than those without, highlighting its significance as an independent risk factor.

Minimizing blood loss during surgery could enhance outcomes and reduce complications for pancreatic surgery patients.