An integrated nutritional and immune-inflammation score significantly predicts disease-free survival in colorectal cancer patients post-surgery.

• The new n-sii and n-siri scores achieved area under the curve values of 0.829 and 0.850, outperforming traditional indices.
• Patients with a score of 2 face double the risk of progression (HR: 2.442 for n-sii; 2.527 for n-siri) and a reduced disease-free survival of just 31.19 months.

Optimizing patient selection with these scores may enhance surgical outcomes and aid in post-operative management.