New guidelines improve perioperative management for liver resection.

• Strong recommendations for prehabilitation, nutrition, and mobilization to enhance recovery.
• Identification of significant gaps in evidence, especially around thromboprophylaxis and post-hepatectomy liver failure management.

Surgeons should standardize practices and collaborate on research to tackle these gaps and improve patient outcomes.

• Expert panel reached consensus through a modified Delphi process, analyzing over 200 studies.