A preventive care strategy can significantly reduce the risk of acute kidney injury (AKI) in high-risk surgical patients.

• Moderate or severe AKI occurred in 14.4% of patients receiving the intervention versus 22.3% in the control group (odds ratio 0.57, p=0.0002).
• Number needed to treat to prevent one case of AKI is 12.

Adverse event rates were similar between the two groups, suggesting safety of the strategy.

• Common adverse events like atrial fibrillation and significant bleeding were not statistically different between groups.