Early-onset pancreatic cancer is surging, demanding attention from surgeons.

• In 2021, there were 31,531 new cases and 26,996 deaths worldwide.
• Asia, particularly East Asia, accounts for the highest burden, with developing nations like China and India leading.
• Risk factors differ; high fasting plasma glucose is not a primary risk for early-onset cases.

Surgeons should prioritize screening and tailored interventions for older males and high-risk populations.