A new model predicts recurrence and mortality for hepatocellular carcinoma (HCC) patients post-surgery, enhancing patient management.

• The Random Survival Forest model identifies high-risk patients, showing a 5-year recurrence rate of 87.3% vs. 51.5% in low-risk patients (training) and 75.9% vs. 64.8% (validation).
• High-risk patients have a 5-year mortality rate of 56.0% vs. 15.3% (training) and 50.0% vs. 23.1% (validation).

This model guides adjuvant therapy decisions, potentially improving long-term outcomes.

• Key factors include diabetes, tumor numbers, and albumin levels.