Women post-major surgery face greater mortality risks linked to complications.

• Female patients had higher failure to rescue rates at 17.5% versus 15.9% for males.
• They also showed higher odds of 30-day mortality (odds ratio: 1.11).

Targeted strategies are essential to address these disparities and improve surgical outcomes for female patients.

• Serious complications were somewhat lower in females (31.2% vs 36.5%), but recovery efforts were less effective.