Single anastomosis sleeve ileal bypass is a promising option for treating obesity and its related conditions.

• Significant weight loss achieved: 63% at 6 months, 82% at 12 months, and 93% at 24 months.
• High remission rates for conditions like diabetes (93%) and hypertension (79%).

Most complications are mild, with a mean rate of 14%. No reported deaths highlight its safety for patients.

Surgeons should consider SASI bypass as a viable choice for patients with a high BMI and multiple obesity-related comorbidities.