Routine administration of surgical antimicrobial prophylaxis before low-risk cholecystectomies significantly decreases surgical site infections.

• SSI rate dropped by 50% in patients receiving prophylaxis (1.1% with SAP vs. 2.2% without).
• 9,269 patients (74%) received prophylaxis; number needed to treat to prevent one SSI is 100.

Implementing routine prophylaxis may improve patient outcomes in low-risk cases.

• Study included 12,521 patients from 66 Swiss hospitals over 11 years.