Fluid management impacts outcomes in pancreaticoduodenectomy for localized cancer.

• Excessive fluid can lead to complications like postoperative pancreatic fistula and increased inflammatory responses.
• A shift towards restrictive fluid regimens has shown to reduce overall complications and shorten hospital stays.
• Goal-directed fluid therapy (GDFT) tailors fluid delivery, improving outcomes but requires careful balance to avoid hypoperfusion.

Future studies must aim for standardized protocols and long-term data to refine practices.