Cryoablation is a safe and effective treatment for locally advanced pancreatic cancer (LAPC), enhancing patient outcomes when surgery isn’t feasible.

• No perioperative deaths; smooth surgeries across all patients.
• Postoperative pancreatic fistulas occurred in 75% of cases, but most were manageable.

This technique can prolong survival and improve quality of life by addressing tumor progression directly.

• 12.5% experienced delayed gastric emptying; CA 19-9 levels stayed low at 30 days post-op.

Consider cryoablation as a key option in multidisciplinary care for LAPC patients.