Oral hydrocortisone sodium succinate with aluminum phosphate gel significantly reduces postoperative esophageal stricture after endoscopic submucosal dissection (ESD).

• This combination therapy lowers stricture risk by 92.5% compared to standard care (relative risk = 0.075).
• Using polyglycolic acid sheets with fibrin glue minimizes the need for endoscopic balloon dilatation, reducing sessions by an average of 6.4.

Incorporating these therapies can enhance surgical outcomes and patient comfort post-ESD.