Pancreatectomy outcomes for pancreatic neuroendocrine tumors (PNETs) are consistent, regardless of whether they arise from sporadic cases or genetic syndromes like MEN1 and VHL.

• In a study of 1,527 patients, 73 had MEN1, 26 had VHL, and 1,428 exhibited sporadic PNETs.
• Resection rates varied, with R2 resection at 9.6% for MEN1, compared to 2.6% for sporadic and 3.8% for VHL cases.

Despite key differences in demographics and tumor characteristics, postoperative complications and survival rates remained equivalent. This suggests similar patient management strategies may be applied across these groups.