Surgeons need to consider how perioperative quality of life fluctuates in pancreatic cancer patients to enhance outcomes.

• Quality of life scores significantly change between perioperative stages (p < 0.001).
• Main issues needing attention: pain and nausea in the first week, social functioning before discharge, and fatigue one month post-op.

Timely interventions on these factors can improve care and patient well-being.

• 66.79% of patients had ductal adenocarcinoma, indicating a majority skew in disease type affecting recovery profiles.