Correlation between primary and secondary cancers

Many cancer survivors are at risk of developing a second primary cancer (SPC), which affects their prognosis. This study conducted a systematic review and meta-analysis of 9 million cancer patients to explore correlations between SPCs and first primary cancers (FPCs). The analysis revealed specific associations between certain FPCs and the development of SPCs in different organs. For example, patients with gynecological or thyroid cancer had a higher likelihood of developing breast or colorectal cancer as an SPC. These findings emphasize the importance of close clinical follow-up and monitoring for early diagnosis and better screening of SPCs in patients with relevant FPCs.