Genomic and clinicopathologic characteristics of small bowel adenocarcinoma

The study examined 68 surgical resections from patients with small bowel adenocarcinoma (SBA) to investigate the correlation between immunophenotypes, DNA mismatch repair status, genomic profiling, and clinicopathologic characteristics. The results showed that the expression of certain proteins correlated with tumor location, histologic type, and TNM stage. Muc1 and muc4 expression were associated with worse prognosis, while muc2 expression correlated with better prognosis. Gastric-type SBA exhibited distinct molecular pathways compared to intestinal-type SBA. These findings provide insights into the genomic and clinicopathologic characteristics of SBA.