Adding pyloroplasty during esophagectomy significantly lowers the risk of short-term complications.

• Patients undergoing pyloroplasty had a pneumonia or anastomotic leak rate of 18% compared to 27% in those without the procedure.
• The trial led to early stopping when superiority of pyloroplasty was confirmed with a 90% probability.

Surgeons can confidently incorporate pyloroplasty to enhance patient outcomes in these procedures.