Selective alpha blockers lower medication expenses but yield similar surgical outcomes for pheochromocytoma.

• Median preoperative medication cost was $19.73 for selective vs. $1,033.70 for nonselective (p < 0.001).
• Total admission costs were nearly identical: $31,104.47 for selective vs. $31,471.90 for nonselective (p = 0.428).

Choosing selective blockers may optimize preoperative costs without compromising patient care.

• No significant differences in length of stay or post-discharge costs based on the alpha-blockade method.