Early enteral nutrition (EEN) via nasojejunal tube reduces complications after pancreatoduodenectomy compared to oral nutrition (ON).

• EEN patients had a mean 90-day complication index of 25.5 vs. 35.8 for ON (p = .02).
• Overall morbidity was slightly higher in ON (51/59) vs. EEN (45/59), but not statistically significant.

Implementing EEN in nutritionally at-risk patients can improve surgical outcomes without increasing specific complication rates.

• Nasojejunal tube was replaced in 14 EEN patients due to removal.