This study assesses 11 clinical risk scores to enhance patient selection for liver resection in colorectal cancer.

• Median overall survival after surgery was 26 months for 528 patients.
• The Comprehensive Evaluation of Relapse Risk (CERR) score showed strong predictive performance with an area under the curve of 0.654 for 1-year survival and 0.62 for 5-year survival.
• All risk scores, except one, effectively stratified patients by long-term survival.

Utilizing these scores can refine surgical decision-making and optimize patient outcomes in liver resections.