Hepatic vein occlusion with portal vein embolization significantly boosts future liver remnant growth in 2-stage hepatectomies, impacting patient selection and stage feasibility.

• Hepatic vein occlusion combined with portal vein embolization led to a 36.8% increase in future liver remnant, 24.5% higher than portal vein embolization alone (p < .01).
• Associating liver partition and portal vein ligation resulted in a 68.5% future liver remnant increase and a 95% feasibility rate for stage 2.

Surgeons should consider these strategies for optimal liver regeneration planning in patients.

• Morbidity and mortality rates were similar among approaches, highlighting their safety profiles.