Minimally invasive surgery (MIS) shows promise for pT4 colon cancer without compromising long-term oncologic outcomes.

• In a study of 1,850 patients, those undergoing MIS had 2.4 times fewer major complications compared to open surgery.
• After 42 months of follow-up, overall recurrence rates were similar for both groups, with better disease-free survival (DFS) and overall survival (OS) for the MIS group.

Well-selected patients—such as those with favorable clinical characteristics—can benefit from MIS, enhancing recovery with reduced complications.