Minimally invasive hepatopancreatobiliary surgery leads to significant cost savings and shorter recovery compared to open surgery.

• 1-year total expenditures were reduced by $33,255.
• Hospital stays were 2.6 days shorter, with a 30-day readmission rate of 29% lower (odds ratio 0.71).

Surgeons should consider the benefits of minimally invasive techniques for enhanced patient outcomes and cost efficiency.

• Out-of-pocket patient spending was not significantly lower overall, highlighting variable financial impacts based on insurance plan types.