A new consensus framework for hepatocellular carcinoma (HCC) could transform surgical decision-making and patient outcomes.

• The BEACON-HCC system integrates clinical features like tumor burden and vascular invasion for more precise treatment options.
• In a pilot with 29 cases, expert decisions matched BEACON-HCC recommendations 96.6% of the time, compared to 72.4% for current standards.

This framework aligns treatment with tumor biology, paving the way for expanded therapeutic strategies in North America.

• It includes emerging modalities like external beam radiation therapy and transarterial radioembolization.