New Guidelines for Pancreatic Cyst and HCC Surveillance in Seniors

This update offers critical insights on discontinuing surveillance for pancreatic cystic lesions (PCLs) and hepatocellular carcinoma (HCC) in older adults, emphasizing a tailored approach based on individual risk.

  • Patients over 65 with stable PCLs ≤15 mm for 5 years should consider ending routine surveillance following thorough discussion, as risky interventions may outweigh benefits.
  • In those >75 with stable PCLs <30 mm, discussions on the minimal risk of cancer may lead to surveillance cessation after 5 years if they understand the context.
  • HCC surveillance in seniors with cirrhosis should not be age-based alone but rather consider life expectancy and comorbidity, with cessation recommended if life expectancy is less than 1–2 years.

Surgeons should integrate these guidelines into decision-making discussions to optimize patient outcomes.

Practice Guideline by Das KK, Serper M and Vege SS in Clin Gastroenterol Hepatol

Copyright © 2026 The Author(s). Published by Elsevier Inc. All rights reserved.

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