Accurate Prediction of Anti-TNF Treatment Failure in Perianal Crohn’s Disease Using MRI-Based Model

Researchers developed an MRI-based prediction model for anti-TNF treatment failure in perianal Crohn’s disease. The model, based on clinical and radiologic parameters, accurately predicts the likelihood of treatment failure and outperforms existing imaging-based indices. The study included 221 patients, with treatment failure occurring in 46% of cases. The prediction model included age at diagnosis, time to initiate treatment, smoking, and eight MRI characteristics. The full and simplified MRI models had fair discriminatory capacity for treatment failure.