Rectal Indomethacin Reduces Post-Operative Hyperamylasemia in Pancreatoduodenectomy

A randomized controlled trial assessed the efficacy of rectal indomethacin in preventing post-operative hyperamylasemia (POH) following pancreatoduodenectomy (PD). The study included 44 patients who either received 100mg of indomethacin per-rectally or standard care. The intervention arm had a significantly lower incidence of POH (28.6% vs. 60.9%) and reduced severity of delayed gastric emptying (DGE) compared to the control arm. While other variables showed a trend towards improvement, they did not reach statistical significance. The study concludes that perioperative per-rectal indomethacin administration effectively decreases the incidence of POH following PD.