Non-autologous reinforcement reduces postoperative pancreatic fistula after distal pancreatectomy: Meta-analysis of randomized clinical trials

Non-autologous reinforcement of the pancreatic stump following distal pancreatectomy significantly reduces the rate of postoperative pancreatic fistula (POPF), according to a meta-analysis of nine randomized clinical trials. The pooled analysis found a lower rate of POPF in the non-autologous reinforcement group compared to the non-reinforcement group. Heterogeneity was observed in the 95% predictive interval, but subgroup analysis showed that non-autologous reinforcement, excluding “Tachosil®,” was effective. There were no significant differences between the two groups regarding secondary outcomes.