High Resection to Exploration Ratios and Variable Survival Outcomes in Pancreatic Ductal Adenocarcinoma Patients

Researchers conducted a study to investigate resection to exploration ratios (RER) and outcomes in patients with pancreatic ductal adenocarcinoma (PDAC). The overall RER was found to be 89.7%, with higher ratios observed in upfront explorations compared to post-neoadjuvant explorations. The primary reasons for uncompleted resection were occult metastases in presumed resectable/borderline resectable disease and local unresectability in locally advanced disease. Uncompleted resection was associated with a median survival of around one year, while post-pancreatectomy survival varied depending on the treatment setting, with a median of 36.9 months in the upfront setting and 29.5 months following neoadjuvant treatment.