Discontinuous growth pattern is an independent adverse predictor of survival outcomes in esophageal adenocarcinoma.

Discontinuous growth (DG) in esophageal adenocarcinoma (EAC) is associated with adverse clinicopathologic features and worse patient outcomes. DG was found to be an independent adverse predictor of survival outcomes in EAC, even after adjusting for other factors such as tumor size and stage. This multi-institutional study highlights the significance of DG and emphasizes the need to consider it in the evaluation and staging of both treatment-naïve and treated EAC tumors.