A modified dosing protocol (MDP) for hepatic arterial infusion (HAI) with reduced floxuridine starting dose resulted in fewer dose holds and reductions compared to the standard dosing protocol (SDP). MDP patients completed more cycles before dose reduction, received more overall cycles, and had fewer instances of treatment-ending biliary toxicity. Conversion to hepatic resection was similar between the groups.
• Why it matters: Reducing disruptions in treatment for unresectable colorectal liver metastases improves outcomes.
Journal Article by Schwantes IR, Patel RK (…) Mayo SC et 8 al. in Ann Surg Oncol
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