Three-day antibiotic regimen shows non-inferiority to seven-day regimen

A study involving 256 patients undergoing left-sided colorectal surgery assessed the effectiveness of a three-day versus a seven-day selective digestive decontamination (SDD) regimen. Results indicated anastomotic leakage rates of 1.2% for the three-day group compared to 5.2% for the seven-day group, and surgical site infections were 3.6% and 5.8%, respectively. The shortened three-day regimen was found to be non-inferior to the seven-day regimen in preventing infectious complications.