High 30-Day Morbidity and Mortality Rates for PPU Surgery

In an international cohort study of 1,874 patients with perforated peptic ulcer (PPU), researchers found a 30-day morbidity rate of 48.5% and a mortality rate of 9.3%. Key factors affecting these rates included age over 50, female gender, shock on admission, and acute kidney injury, all significantly associated with increased morbidity and mortality. Delayed presentation correlated with higher morbidity but not mortality. The study highlights critical insights for improving surgical outcomes in PPU patients.