EUS-FNA/B shows strong diagnostic performance for PANNETs

A meta-analysis involving 2,978 patients confirms that endoscopic ultrasound-guided fine needle acquisition (EUS-FNA/B) is an effective method for diagnosing and pre-operatively grading pancreatic neuroendocrine tumors (PANNETs). The overall concordance rate with surgical grading was 0.77, with a notable increase in the G1 subgroup (0.88). Notably, fine needle biopsy (FNB) outperformed fine needle aspiration (FNA) in both sample adequacy and fewer passes required. Adverse events were minimal, indicating a safe procedure.