Liver resection improves survival in colorectal metastases with extrahepatic disease

A population-based analysis of 170,978 patients revealed that liver resection significantly enhances overall survival for those with colorectal liver metastases and concurrent extrahepatic disease. Among 62,003 patients with this dual condition, only 6% underwent liver resection, yet they experienced markedly better median overall survival (52 months) compared to those without resection (27 months). Factors influencing selection included younger age, fewer comorbidities, and the presence of single-site extrahepatic disease.