Epithelial type influences postoperative outcomes in IPMNs

A multicenter analysis of 556 patients with intraductal papillary mucinous neoplasms indicated that epithelial types significantly affect postoperative results. The pancreatobiliary type demonstrated a notably higher 10-year cumulative incidence of metachronous pancreatic ductal adenocarcinoma (22.7%) and high-risk lesions (37.2%) compared to gastric and intestinal types. Five-year disease-specific survival rates varied substantially, with 76.1% for the pancreatobiliary type versus 92.5% for gastric and 96.0% for intestinal types, underscoring the need for tailored postoperative surveillance.