Liver resection outperforms radiofrequency ablation for small tumors

A systematic review and meta-analysis comparing liver resection (LR) and radiofrequency ablation (RFA) for solitary hepatocellular carcinoma (HCC) ≤3 cm highlights that LR offers superior overall survival, disease-free survival, and recurrence-free survival compared to RFA, particularly for lesions ≤2 cm. While no significant differences were found in randomized controlled trials, cohort studies indicated LR’s advantages, establishing it as the preferable option for small HCC treatment. Additional randomized trials are necessary to confirm these findings.