Faecal immunochemical test screening matches colonoscopy in safety

A pragmatic trial involving 57,404 individuals revealed that faecal immunochemical test (FIT) screening is non-inferior to colonoscopy in reducing colorectal cancer mortality over 10 years. Participation rates were higher for FIT at 39.9% compared to colonoscopy’s 31.8%. The colorectal cancer mortality risk was nearly identical between the two groups, suggesting that a FIT-based screening program is an effective alternative to colonoscopy, potentially increasing screening participation among the average-risk population.