Distinct prognostic implications observed in pancreatic neuroendocrine neoplasms

Findings indicate significant differences between insulinomas and non-functional pancreatic neuroendocrine neoplasms (nf-pnens) regarding prognosis and tumor biology. nf-pnens exhibited higher rates of lymph node involvement, perineural invasion, and more advanced tumor grades. The study’s multivariate analysis revealed that nf-pnens with lymph node metastasis and high grading correlated with reduced recurrence-free survival. Genetically, distinct somatic mutations and copy number variations were noted, emphasizing the need for tailored surgical management and follow-up strategies for these neoplasms.