In a study validating the Memorial Sloan Kettering clinical calculator for predicting freedom from colon cancer recurrence, results demonstrated its accuracy. The calculator, based on clinical and molecular variables, was originally developed with selective microsatellite instability testing. However, when tested with data from patients thoroughly examined for instability, it remained reliable. The concordance index was 0.748, signifying good discrimination and calibration, and even in a secondary analysis considering tumor deposits, it maintained a high concordance index of 0.755. This confirms the calculator’s precision in predicting colon cancer recurrence.
Journal Article by Khan A, Thompson H (…) Weiser MR et 10 al. in Dis Colon Rectum
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