Ileocecal resection enhances microbial health in Crohn’s disease.

A multi-omics analysis of ileal mucosa and mesentery samples from Crohn’s disease patients illustrates notable improvements in microbial health following ileocecal resection. Among 34 patients studied, significant spatial changes in microbiota and metabolites were identified pre- and post-surgery. Metabolites were further analyzed, revealing crucial insights into their roles. These findings underscore ileocecal resection as a potentially effective treatment for inducing remission in Crohn’s disease, paving the way for microbiome-driven therapeutic strategies.