Low preoperative serum protein concentration increases staple-line leak risk.

In a study involving 1,669 patients undergoing sleeve gastrectomy, staple-line leaks were significantly associated with low preoperative serum protein concentrations (spc). Patients with leaks had a median spc of 6.8 g/L compared to 7.1 g/L in those without leaks. Higher spc values reduced leak risk (odds ratio of 0.20). Additionally, major intraoperative bleeding and blood transfusion needs were linked to increased leak rates. Improving nutritional assessment could help mitigate these complications.